ABSTRACT
Objective To establish HPLC fingerprint of Xinjiaxiangruyin standard decoction soasto provide an analytical method for the quality control of Xinjiaxiangruyin granules. Methods HPLC was conducted on a phenonmenex Luna C18 column us?ing acetonitrile-0.1%H3PO4 in gradient elution modes as mobile phase,where detection wavelength was 280 nm and detection time was 130 min. With chlorogenic acid as reference peak,the Edition 2012 ofchromatographic fingerprint similarity evaluation systemsoftware was used to establish the standard decoction reference fingerprint,which was then compared with the fingerprint of 5 batchs of the granules for similarity evaluation. Results The similarity of the fingerprints between the 5 batches of granules and the standard decoction was higher than 0.90. Conclusion The method is simple,stable and reproducible,which could be used for the quality control of the granules as an adjuvant method.